the most heavy load friendly route is to take 395 into bishop, and then cut over into nevada on the s6, and take the 95/alt95 up into fernley/wadsworth.
Agreed, I just got back from Lake Tahoe and the CHP was stopping traffic just outside of Bishop and so we turned around and took the S6 route, very flat and didn't take that much longer than taking 395 all the way.
Joel's advice is also worth repeating- Don't drive tired! If you are pounding redbulls and driving with the stereo cranked up full volume and sticking your head out the window to stay awake, just pull over and get some sleep. Co-drivers need to stay awake too! I find that not driving at night is a lot safer too.